Lorazepam

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Dosage

Lorazepam dosage must be adjusted based on the patient's response; it's critical to strike a balance between the bare minimum dose required to alleviate symptoms and the shortest possible duration. Furthermore, patients who abruptly stop taking the therapy appear to be at risk of developing withdrawal symptoms, which is why there is a recommendation for a gradual reduction in the drug's dosage; at the same time, any dose increase should be done gradually to avoid adverse reactions.

Lorazepam can be used in conjunction with antidepressant therapy to strengthen, complete, and partially accelerate the effect. It has a positive effect on mood while also protecting against psychic stress.

The recommended dose varies depending on the type and severity of the disease being treated; most patients respond to two or three 1 milligram doses per day, with 2.5 milligram tablets being used in the most severe cases. It is not recommended that the elderly patient take more than 2 milligrams per day.

It is recommended that all patients undergoing therapy receive a higher dose in the evening in order to get a good night's sleep and to make the most of the daytime hours by favoring daily activities.

Lorazepam's plasma concentration is reached within two to three hours of administration, and the drug's half-life is about 14 hours. Lorazepam is available in three forms: solution, tablet, and injectable.

Contraindications to the use of Lorazepam

Lorazepam is not recommended for people who have a history of benzodiazepine hypersensitivity, myasthenia gravis, respiratory failure, severe syndrome, sleep apnea, or severe liver failure.

Pregnancy

The administration of Lorazepam during pregnancy and lactation is not indicated.

Interactions

When lorazepam is taken in conjunction with alcoholic beverages, the sedative effect is amplified. The prescriber must carefully assess the interaction with other psychotropic drugs.

When combined with opioids, alcohol, or other CNS-acting drugs like neuroleptics, hypnotics, antidepressants, or antiepileptics, it can cause depressive effects in the central nervous system (CNS).

Lorazepam and side effects

Drowsiness during the day, altered libido, ataxia, mental confusion, nausea, muscle weakness, and fatigue are all possible side effects of lorazepam. Dizziness, hypothermia, urinary retention, and liver dysfunction are more uncommon.

Overdose

It manifests as drowsiness, dysarthria, mental confusion, and coma states in varying degrees of CNS depression. Overdose problems are most common when alcohol and/or other medications are combined.

In order to induce vomiting (within one hour of dosing) in alert patients or to perform gastric lavage with airway protection in unconscious patients, it may be necessary to induce vomiting (within one hour of dosing). To reduce absorption, activated charcoal should be used.

Flumazenil, a commercially available antidote, can be used to block the binding of benzodiazepines to the GABA receptor in cases of acute poisoning.

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