Mogadon / Nitrazepam

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What's in Mogadon?

The white tablet contains 5 mg nitrazepam as the active ingredient.

What is Mogadon and when is it used?

You received Mogadon on the prescription of your doctor and should only take it as directed. The active ingredient is nitrazepam and belongs to the group of benzodiazepines. Mogadon has a pronounced sleep-promoting effect. Taken in the evening, it works within 30 to 60 minutes and helps you sleep for six to eight hours. Your doctor or health care professional prescribes Mogadon when our need for treatment for insomnia sufferers. These arise, for example, as a result of irritability, overuse, anger, fear, worry, tension, and depression. Children should not take the preparation if they have sleep disorders . In addition to its sleep-inducing effects, Mogadon also has antispasmodic properties . So don't be surprised if the specialist prescribes higher doses of Mogadon for a child in these cases.

What precautions should be taken?

If you still feel drowsy or dull the day after taking it, it is likely that the amount taken was too large for you. Older people in particular often react more strongly to sleeping pills. If you make such a determination, seek advice from your doctor or pharmacist.

When should Mogadon not be used?

Mogadon should not be used in

• Hypersensitivity to nitrazepam, other benzodiazepines or any other component of the drug,
• severe respiratory dysfunction,
• severe muscle weakness (myasthenia gravis),
• Stop breathing during sleep (sleep apnea syndrome)
• severe liver dysfunction,
• Movement disorders of muscle groups that result from the destruction of nerve cells, especially in the cerebellum or spinal cord (cerebellar or spinal ataxias),
• acute poisoning with alcohol, sedatives, sleeping pills, painkillers or psychotropic drugs (neuroleptics, antidepressants, lithium),
• Insomnia in children and adolescents.

• What side effects can Mogadon have?

  Frequent: mood disturbances, mental confusion, depression (manifestation of pre-existing depression), lightheadedness, headache, dizziness, memory impairment, double vision, difficulty breathing, increased mucus formation in the bronchi, muscle weakness (this may increase the risk of falls), urinary retention or involuntary and uncontrolled loss of urine, tiredness.

  Occasional: delirium, sleep disturbances, impaired thinking ability, balance disturbances, motor disturbances, tremors, motor coordination disturbances.

  Rare: changes in the blood picture, allergic skin reactions, impaired sex drive, addiction, withdrawal symptoms, mood changes, anxiety, agitation, drug abuse, excitement, aggression, delusional ideas, anger, nightmares, hallucinations, disorders psychotic, epilepsy, spinning dizziness, visual disturbance, arterial hypotension, nausea, abdominal pain, diarrhea, dry mouth, constipation, increased salivary flow, gastrointestinal disturbances, liver function disturbances, jaundice, rash, hives, itching, inflammation skin, muscle cramps, irritability, accentuated return of initial symptoms after discontinuation of treatment.

  Rarely, severe allergic and inflammatory reactions to the skin and mucous membranes may also occur (rash and blisters, e.g. affecting the hands, feet, arms, mouth, nose and genitals), which may also be accompanied by severe impairment of general well-being and fever. In very rare cases, hypersensitivity reactions, anaphylactic reactions, angioedema (swelling of the skin and / or mucous membranes) may also occur. In such cases, treatment should be stopped immediately and a doctor should be consulted.

  Frequency not known: Speech disturbances have been observed during treatment with Mogadon.

  If you notice any side effects not described here, you should inform your doctor or pharmacist.

  
  What else needs to be taken into account?

  The medicinal product should not be used beyond the date indicated with "EXP" on the container.

  Store at room temperature (15-25 ° C) and out of the reach of children.

  Your doctor or pharmacist, who have detailed professional information, can give you further information.

  How to use Mogadon?

  Adults: usually 1 tablet in the evening before bedtime.

  A half dosage (½ tablet) is usually sufficient for elderly, thin or particularly sensitive patients.

  In the presence of brain disease, older people should not take more than one 5 mg Mogadon tablet per day.

  The tablets can be chewed, swallowed whole or dissolved in water.

  Children suffering from seizures (epilepsy): the specialist decides in each individual case whether treatment with Mogadon is appropriate and also determines the appropriate dosage for your child. The dosage indicated should not be changed without consulting your doctor.

  Do not change the prescribed dosage on your own initiative. If you think that the action of the medicine is too weak or too strong, talk to your doctor or pharmacist.

   

  When is caution required when administering Mogadon?

  Before using Mogadon as a sleeping pill, a thorough medical examination should be conducted to establish the cause of the insomnia.

  Addiction

  After taking it for a few weeks, some loss of sleep inducing effect may occur.

  Risk of addiction

  Taking Mogadon, as with all benzodiazepine preparations, can cause addiction. This can occur especially as a result of uninterrupted intake for prolonged periods (in some cases already after a few weeks) and in the case of high doses. The risk increases in cases of alcoholism, drug abuse and certain mental illnesses.

  To minimize the risk of an addiction developing, observe the following:

  • only take Mogadon if your doctor prescribes it;
  • do not under any circumstances increase the dose prescribed by your doctor;
  • inform your doctor that you intend to stop taking the medicine; in case of prolonged use, a gradual reduction of the dose is recommended;
  • the doctor will periodically decide whether to continue the treatment;
  • the intake for prolonged periods (generally for more than four weeks) can only be done under strict medical supervision.

  Manifestations of abstinence

  Suddenly stopping the drug may result in withdrawal symptoms, even if the drug was taken for a short time and at normal dosage. Depression, headaches, difficulty concentrating, muscle weakness, nervousness, unusually heightened anxiety, states of tension, tremor, restlessness, mental confusion, mood changes, insomnia, irritability, sweating, diarrhea, muscle cramps and abdominal, perception disturbances, as well as, rarely, delusional ideas and seizures. In severe cases, derealization (distorted perception of the environment), depersonalization (dissociation of the sense of self), numbness and tingling in the arms and legs, hypersensitivity to light, can also be observed. to noises and body contact, hallucinations and epileptic seizures. These manifestations usually subside after two to three weeks.

  Marked recurrence of insomnia and anxiety after discontinuation

  Upon discontinuation of treatment, the same symptoms that led to treatment with Mogadon may reappear in a transient and marked form. They can be accompanied by other reactions, such as mood swings, anxiety and agitation. Abrupt discontinuation of treatment increases the risk of withdrawal symptoms or accentuated reappearance of insomnia, therefore gradual dose reduction is recommended.

  Memory disturbances

  Benzodiazepines can cause memory gaps related to the post-intake period. This state usually occurs a few hours after taking it and can last for several hours. This means that after taking the medicine you may take actions that you may not remember later. This risk increases with increasing dosage and concomitant alcohol intake. Sufficiently long and uninterrupted sleep (7-8 hours) can reduce this risk. If he is awakened at the moment when the drug exerts its most intense effect, his memory capacity may be reduced.

  Psychic and "paradoxical" reactions

  When benzodiazepines are used, especially in elderly patients or children, psychic and so-called "paradoxical" reactions may occur, i.e. effects contrary to those expected by the action of the drug such as, for example, aggression, restlessness, mental confusion, agitation, irritability , excitability, delusional ideas, temper tantrums, nightmares, hallucinations, psychosis, inappropriate behavior and other behavioral disorders. Pre-existing depressions with suicidal tendencies are also possible. In such cases, treatment with this medicine should be discontinued.

  Switching from one benzodiazepine drug to another should only be done by prescription.

  Tell your doctor about any heart, respiratory, kidney or liver disease, as well as if you have or have had in the past from alcohol, medication or drug addiction.

  Due to the relaxing effect on the muscles, the risk of falls and consequently of bone fractures may be increased, especially in elderly people who get up at night.

  Tell your doctor if you have an intolerability to certain types of sugars (lactose intolerance).

  This medicine can reduce the ability to react, the ability to drive a vehicle and the ability to use tools or machines! In case of insufficient sleep duration, the risk of a reduction in the level of attention also increases.

  Pre-existing depressions may develop or worsen during treatment with benzodiazepines, including Mogadon. If you suffer from depression, you can only take Mogadon if the symptoms of this depression are treated with suitable medicines.

  Simultaneous intake of alcohol and / or medications with tranquilizing action

  Alcoholic beverages and medications with a tranquilizing or sedative (sleep-promoting) action (e.g. tranquilizers, sleeping pills, antidepressants, antipsychotics, anxiolytics, various pain relievers, antiallergics and other preparations that act on the brain and nerves, narcolepsy medications , antihypertensives, beta blockers, as well as muscle relaxants) may possibly enhance the effect of Mogadon. Individual reactions are unpredictable and may be, for example, inaccurate, clumsy or slow. The association with alcohol and / or with these medications can also cause excessive sedation, up to a state similar to sleep and an impairment (up to inhibition) of breathing and / or the cardiovascular system. Therefore, if you are to take Mogadon as a sleeping pill,

  The simultaneous intake of valerian can enhance or reduce the effect of Mogadon.

  The combination with strong painkillers (eg opioids) can lead to an excessive feeling of euphoria and thus lead to psychological dependence more quickly.

  The concomitant use of Mogadon and opioids (strong pain relievers, addiction substitution medications and some antitussive medications) increases the risk of drowsiness, breathlessness, coma and can be fatal. Consequently, concomitant use should be avoided if possible.

  If your doctor prescribes Mogadon in combination with opioid medicines, the dose and duration of concomitant treatment should be limited by your doctor.

  It may be helpful to inform friends or relatives of the aforementioned effects. Contact your doctor if you suddenly feel drowsy or wheezy.

  Other active substances can also enhance the action of benzodiazepines and benzodiazepine-like active substances. Examples are medicaments for fungal diseases (azole antifungals), medications for gastric hyperacidity (eg cimetidine, omeprazole), HIV medications (antiretroviral protease inhibitors), contraceptives ("pill" ), antibiotics such as erythromycin, medicines for hypertension or coronary heart disease (so-called calcium channel blockers), antidepressants (selective serotonin reuptake inhibitors), medicines used to treat alcohol dependence (such as disulfiram) or antiepileptics (eg valproic acid, topiramate, hydantoin and barbiturates).

  Some medicaments for serious infectious diseases such as p. ex. tuberculosis (rifampicin) or medications for asthma or 'smoker's lung' (chronic obstructive pulmonary disease) and even St. John's wort preparations may reduce the effect or duration of action of benzodiazepines.

  Tell your doctor or pharmacist just in case

  • suffer from other diseases,
  • suffer from allergies or
  • take or apply other medicines externally (even if purchased on your own initiative)!

  
  Can Mogadon be given during pregnancy or breastfeeding?

  Tell your doctor if you are pregnant, intend to become pregnant or if you are breastfeeding.

  In the event of an established or desired pregnancy, Mogadon can only be taken on prescription.

  Mogadon passes into breast milk. Therefore, during breastfeeding, you must give up taking Mogadon.

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